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New Gout Drugs ??? Pegloticase Continues Its Hopeful Path
In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.
31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial. It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.
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Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.
It has been having a decent degree of success. Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial. We are proud to say we have dominance in the say of food good for gout. This is because we have read vastly and extensively on food good for gout.
HOW PEGLOTICASE WORKS What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove. The development of food good for gout has been explained in detail in this article on food good for gout. Read it to find something interesting and surprising!
In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers.
May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.
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Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.
SIDE EFFECTS Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes. Producing such an interesting anecdote on food good for gout took a lot of time and hard work. So it would be enhancing to us to learn that you have made good use of this hard work!
In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways.
TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.
Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.
NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.
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Learn More about Natural Gout Remedy
When a gout attack strikes it's usually excruciatingly painful, leaving most sufferers willing to do almost anything to make the pain go away. Because for some people, even when they do their best to eat the right diet, and take all of the other precautions that are suggested by medical professionals, an attack can occur. There are a few things you can do right away to stop your gout attack from... 
Gout is a health problem resulting because of the deposit of uric acid crystals in the joints and surrounding tissues. It is characterized by an excess of uric acid in the body that deposits in different parts of the body leading to recurring attacks of joint inflammation. We know two types of gout: acute and chronic. The most severe phase of gout is chronic gout that beside joint inflammation...
Gout attacks occur suddenly in most of the cases. The first attack is surely going to develop at night, people getting to wake up feeling an extreme joint pain. During gout attack people usually develop the following symptoms: sudden and severe joint pain, swelling, reddish skin around the affected joints and extreme sensitivity in those areas.
All these symptoms might be a cause of an...
Gout is a painful and sudden illness that can affect joints. It is caused by the accumulation of excess uric acid, which is normally removed through the urine. The crystals of uric acid can then accumulate in joints and cause inflammation and pain. Often patients are not able to get to their healthcare provider right away. If it is a first attack the symptoms can be alarming. Fortunately, it is...
This is the second article of a series about this diet. Please see Natural Gout Treatment - The Rules Of A Gout Diet That Had A Lot Of Success, for the first article.
This study, based on the Zone diet, did have a positive effect on markers of insulin resistance: triglycerides, total cholesterol, LDL cholesterol ("bad" cholesterol) fell. HDL cholesterol ("good" cholesterol) did...
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